Literatur Review: Efektifitas  Aerobic Exercise  Terhadap Penurunan Kadar Gula Darah   Pada Tikus Wister Jantan Diabetes Melitus  Tipe 2

Imelda Derang; Chrismis Novalinda Ginting; Linda Chiuman

doi:10.52317/ehj.v8i2.583

Imelda Derang Program Studi S3 Ilmu Kedokteran, Fakultas Kedokteran, Universitas Prima Indonesia, Medan
Chrismis Novalinda Ginting Program Studi S3 Ilmu Kedokteran, Fakultas Kedokteran, Universitas Prima Indonesia, Medan
Linda Chiuman Program Studi S3 Ilmu Kedokteran, Fakultas Kedokteran, Universitas Prima Indonesia, Medan

DOI: https://doi.org/10.52317/ehj.v8i2.583

Keywords: aerobic exercise blood suger level, T2DM

Abstract

Type 2 diabetes mellitus (T2DM) is a multifactorial and global endemic disorder that increases every year in the world due to the inability of body cells to respond to insulin (insulin resistance) so that insulin-producing hormones are disrupted from producing insulin optimally and ultimately there is an insulin deficit, which has an impact on other things. serious and even result in death. Therefore, treatment is needed, including Aerobic exercise, because Aerobic exercise can increase insulin sensitivity, increase homeostatic metabolism, regulate the expression level of oxidative metabolic enzymes, increase the tricarboxylic acid cycle, thereby reducing blood sugar levels (KGD). This article uses a literature study or literature review by searching Google Scholar and PubMed with the keywords aerobic exercise and type 2 diabetes for 5 years of research published between 2015 and 2023. Based on a literature search for articles related to the effect of aerobic exercise on reducing KGD, where All research was tested on experimental animals. Therefore, based on the results of literature studies, it can be concluded that there is an effect of aerobic exercise on reducing KGD in type 2 diabetes (T2DM).

References

Khaledi, K., Hoseini, R., & Gharzi, A. (2023). Effects of aerobic training and vitamin D supplementation on glycemic indices and adipose tissue gene expression in type 2 diabetic rats. Scientific Reports, 13(1)

Gorres-Martens, B. K., Field, T. J., Schmidt, E. R., & Munger, K. A. (2018). Exercise prevents HFD- and OVX-induced type 2 diabetes risk factors by decreasing fat storage and improving fuel utilization. Physiological Reports, 6(13).

Jesmin, S., Shima, T., Soya, M., Takahashi, K., Omura, K., Ogura, K., Koizumi, H., & Soya, H. (2022). Long-term light and moderate exercise intervention similarly prevent both hippocampal and glycemic dysfunction in presymptomatic type 2 diabetic rats. American Journal of Physiology - Endocrinology and Metabolism, 322(3), E219–E230.

Mohamed, B. A., Mahfouz, M. S., & Badr, M. F. (2020). Physical activity and its associated factors in females with type 2 diabetes in Riyadh, Saudi Arabia. PLoS ONE, 15(10 October).

IDF Diabetes Atlas 10th edition. (2021).

Khalili, F., Vaisi-Raygani, A., Shakiba, E., Kohsari, M., Dehbani, M., Naseri, R., Asadi, S., Rahimi, Z., Rahimi, M., & Rahimi, Z. (2022). Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity. Journal of Clinical Laboratory Analysis, 36(1).

Sinclair, J., Ageely, H., Mahfouz, M. S., Hummadi, A. A., Darraj, H., Solan, Y., Allan, R., & Bottoms, L. (2022). Effects of a Home-Based Physical Activity Programme on Blood Biomarkers and Health-Related Quality of Life Indices in Saudi Arabian Type-2 Diabetes Mellitus Patients: Protocol for a Randomised Controlled Trial. International Journal of Environmental Research and Public Health, 19(8).

Yang, Q., Wang, W. W., Ma, P., Ma, Z. X., Hao, M., Adelusi, T. I., Lei-Du, Yin, X. X., & Lu, Q. (2017). Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats. Iranian Journal of Basic Medical Sciences, 20(11), 1220–1226.

Zulkarnain, Satria, D., Yus, T. M., & Rezeki, S. (2015). Pengaruh Latihan Fisik Teratur terhadap Kadar bGlukosa Darah dan Hubungannya dengan Kadar Testosteron Total pada Tikus Model Diabetes. Majalah Kedokteran Bandung.

Infodatin. (2020). Pusat data dan Imformasi Kementrian RI Diabetes-Melitus

Seyedizadeh, S. H., Cheragh-Birjandi, S., & Hamedi Nia, M. R. (2020). The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials). Journal of Diabetes Research, 2020.

Posadzki, P., Pieper, D., Bajpai, R., Makaruk, H., Könsgen, N., Neuhaus, A. L., & Semwal, M. (2020). Exercise/physical activity and health outcomes: an overview of Cochrane systematic reviews. BMC Public Health, 20(1). https://doi.org/10.1186/s12889-020-09855-3

Fritsch, L. J., McCaulley, S. J., Johnson, C. R., Lawson, N. J., & Gorres-Martens, B. K. (2021). Exercise prevents whole body type 2 diabetes risk factors better than estradiol replacement in rats. Journal of Applied Physiology, 131(5), 1520–1531.

Wang. H and Wang. Y (2022). Effects of Different Intensity Exercise on the Patients of Oxidative Stress Factors and Glycemic Control Type 2 Diabetes Mellitus. Hindawi Mathematical Problems in Engineering, Article ID 1992117, 5 pages

Chang, G. R., Hou, P. H., Chen, W. K., Lin, C. T., Tsai, H. P., & Mao, F. C. (2020). Exercise affects blood glucose levels and tissue chromium distribution in high-fat diet-fed C57BL6 mice. Molecules, 25(7).

Dastbarhagh, H., Kargarfard, M., Abedi, H., Bambaeichi, E., & Nazarali, P. (2019). Effects of food restriction and/or aerobic exercise on the GLUT4 in type 2 diabetic male rats. International Journal of Preventive Medicine, 10(1).